HYPOXIA MODULE
CelVivo - 3D Cell Culture System
The CelVivo Hypoxia Module for ClinoStar enables precise oxygen control from atmospheric levels down to 2%, replicating physiological conditions found in tissues like lungs, brain, and tumors. It ensures rapid oxygen level stabilization and maintains hypoxic environments during brief exposures, enhancing the accuracy and reproducibility of 3D cell culture experiments.
Connecting Your Research to in vivo
It’s crucial to accurately establish and monitor oxygen levels during the culture period for mimicking in vivo physiological conditions of tissues or organs.
Oxygen concentrations in the human body vary, ranging from around 12% in the lungs to 5% in the brain, and can be as low as 0.1% in tumor tissues. The ClinoStar hypoxia unit enables the manipulation of in vitro atmospheric composition to tailor it to the specific physiological needs of tissues or organs.
Advantages of adding hypoxia to your ClinoStar 2
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Ability to regulate the level of oxygen from atmospheric to 2%
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Rapid attainment of the set point for the media’s oxygen level is achieved through active gas exchange between the ClinoStar and the ClinoReactor humidification chamber.
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The ClinoReactor’s semi-closed environment temporarily preserves hypoxic conditions for operations within a regular atmospheric oxygen environment (21%). This simplifies short-term handling procedures, such as microscopy observation and documentation.
APPLICATIONS
LIVER
3D structures can be used to study many aspects of liver function, including development, disease modeling (including NASH or fibrosis), cancer, drug screening for efficacy, and toxicology.