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BIO MATERIALS 

REGEMAT provides a variety of thermoplastics, bio inks and hydro gels to support your bioprinting application and enable you to achieve your goals.

Golden Dust

PLA – Regemat 3D

PLA filament with a diameter of 1.75 mm (+- 0.03mm)
Temperature: 200ºC – 220ºC
Choose the color you prefer: Yellow, purple, red, green, blue, white, black or transparent

PLA Filament for Bioprinter

PCL – Regemat 3D

PCL filament with 1.75mm diameter (+- 0.03mm)
Temperature: 90ºC – 145ºC

PCL Filament for Bioprinter
Thermoplastics

Customized PLA / PCL – Regemat 3D

Customized PLA PCL for Bioprinter

Customized PLA or PCL filament with 1.75mm diameter (+ – 0.03mm)

Temperature: 200ºC – 220ºC

Bioinks and Hydrogels
Freeze dried gelatin based bioink

Claro™ BG800

For research use only. Not for human use.

BG800 is a freeze-dried gelatin-based bio-ink modified with methacryloyl groups (GelMA) exhibiting rheological properties tailored for extrusion-based bioprinting. BG800 overcomes clogging and the poor shape-fidelity observed with regular GelMA products without affecting the intrinsic biocompatibility of gelatin and the gel strength of the matrix. BG800 is crosslinkable under UV or visible light, depending on the photo-initiator used in the formulation.

BG800 is produced under high-quality standards of purification, ensuring ultra-low levels of impurities such as methacrylic acid and guaranteeing batch-to-batch consistency.

Human skin collagen type 1

HumaCoat – Human Skin Collagen Type I

For research use only. Not for human use.

Native Human Skin Collagen type l, 1 mg/ml solution. Type I Collagen is the most abundant type of collagen in the human body, as a major structural matrix protein in skin, and many other tissues (bone, tendon, and fibrous connective tissues).
HumaCoat is ideal for many applications including coating tissue culture surfaces or microbeads with a thin layer of collagen to support rapid cell attachment and growth. The optimal collagen concentration used may vary depending on cell type and application and must be titrated for best results.
Type I collagen is isolated from human skin sourced strictly from American Association of Tissue Banks (AATB)
accredited and FDA registered tissue banks and organ
procurement organizations (OPOs). All Humabiologic’s
biomaterials are obtained from tissue partners who comply with requirements for transplantable human tissues under 21 CFR 1271 of the FDA.

HumaMatix – Native Human-Derived ECM

Native human-derived extracellular matrix (lyophilized/solution). The extracellular matrix (ECM) is the
non-cellular component present within all tissues and organs that provides structural and biochemical support to surrounding cells. HumaMatrix is one of the first commercially available native, human-derived extracellular matrix products. Due to its human origin and minimal processing, HumaMatrix retains the native matrix proteins and growth factors found in healthy human tissue including collagen, elastin, laminin, glycosaminoglycans and many other matrix proteins. HumaMatrix is ideal for many applications including coating tissue culture surfaces to support cell attachment and growth or for making hydrogels, and is a perfect alternative to Matrigel.

Human derived extra cellular matrix
Lyophilized human bone derived gelatin

Huma OsteoGelatin – Human Bone Gelatin

For research use only. Not for human use.

Lyophilized human bone-derived gelatin. Gelatin is a
heterogeneous mixture of water-soluble proteins with high average molecular masses. Gelatin proteins are derived by denaturing collagen-rich tissue in water. The mechanical properties of gelatin, such as gel stiffness and compressibility, are related to the average molecular weight of the gelatin proteins and characterized by its Bloom number. Huma OsteoGelatin is the first and only human gelatin in the market derived from bone at Bloom numbers between 90-300 g to meet translation research and regenerative therapies needs. It is ideal for coating tissue culture surfaces with a thin layer of gelatin to support rapid cell attachment and growth or for bioink preparation. This biomaterial can be combined with other human-derived biomaterials, such as HumaDerm, to make completely human-derived tissue engineered composites.

This product is also offered in its methacrylated form, Huma OsteoGelMA,having the ability to be photocrosslinked to generate tunable 3D hydrogels with 3D bioprinting, 3D culturing, and many other tissue engineering applications.

HumaDerm – Human Skin Collagen Type I

For research use only. Not for human use.

Native human skin collagen type l (lyophilized/solution). Type I Collagen is the most abundant type of collagen in the human body, as a major structural matrix protein in skin, and many other tissues (bone, tendon, and fibrous connective tissues). HumaDerm is ideal for many applications including coating tissue culture surfaces to support cell attachment and growth, for 3D bioprinting applications and 3D cell culture.
This product is also offered in its methacrylated form,
HumaDerMA, having the ability to be photocrosslinked to be mechanically tunable for use in 3D bioprinting, 3D culturing, and many other tissue engineering applications.
Type I collagen is isolated from human skin sourced strictly from American Association of Tissue Banks (AATB) accredited and FDA registered tissue banks and organ procurement organizations (OPOs).

Native human skin collagen type 1

EasyGel-INX R100

EasyGel-INX R100 provides all the benefits of gelatin while leveraging BIOINX®'s patented CURADUO® technology. This results in up to 33% faster UV polymerization and, therefore, reduced bioprinting time. It is developed based on natural collagen-derived gelatin modified with photopolymerizable functional groups. In the presence of the supplied XL crosslinker, constructs can be generated with unprecedented efficiency. It exhibits a high analogy to the composition of the natural extracellular matrix and is characterized by high cell viability.

EasyGel-INX R100 is provided in 3ml clear hydrogel cartridges.

GelMa-INX R100

Methacrylated gelatin (GelMA)-based bioinks provide cells with the essential properties of their native environment. GelMA polymerizes easily with a photoinitiator or upon exposure to UV light. GelMA-INX R100 has become one of the standards in tissue engineering and biofabrication worldwide. It is based on natural collagen-derived gelatin modified with photopolymerizable functional groups, thus enabling crosslinking of the hydrogel after bioprinting.

GelMa-INX R100 is provided in a 3ml cartridge ready to bioprint once the appropriate temperature is reached.

Hydromelt-INX R100

Synthetic hydrogel based on BIOINX's patented CURASOL® technology. This technology allows hydrogels to be processed by increasing temperature instead of having to generate solutions. This results in hydrogels with robust mechanical and rheological properties that allow both cell adhesion and proliferation for long periods of time.

Its main advantages include:

  • Biocompatibility.

  • Reproducibility: production under strict quality control.

  • Biological stability: suitable for long-term applications.

  • Processability: The only hydrogel formulation that can be processed as a thermoplastic thanks to CURASOL® technology.

  • Easy handling: delivered in a ready-to-use cartridge.

 

HYDROMELT is supplied as a white solid in a 3 ml prefilled cartridge. The 3D printing-ready bioink is obtained from the post-heated melt of the product.

Synthetic Peptide Bioink

Synthetic peptide hydrogel bioink that forms a nanofibrous network mimicking the extracellular matrix. It has been specifically developed for bioprinting and advanced 3D cell culture applications. This bioink is biocompatible and has been designed to provide versatility to support diverse printing applications, as its
mechanical properties can be tailored to each specific research project.

Format: 250 mg + 10 ml glass bottle (lyophilized peptide + buffer solution).

Synthetic Peptide Bioink functionalized with fibronectin

Synthetic peptide hydrogel bioink functionalized with fibronectin that forms a nanofiber network, mimicking the extracellular matrix. It has been specifically developed for bioprinting and advanced 3D cell culture applications. This bioink is biocompatible and has been designed to support diverse printing applications, as its mechanical properties can be tailored to each specific research project.

Format: 250g+10ml glass jar

Synthetic Peptide Bioink functionalized with collagen

A synthetic peptide hydrogel bioink functionalized with collagen that forms a nanofibrous network, mimicking the extracellular matrix. It has been specifically developed for bioprinting and advanced 3D cell culture applications. This bioink is biocompatible and has been designed to support a variety of printing applications, as its mechanical properties can be tailored to each specific research project.

Format: 250g+10ml glass jar

Sodium Alginate

Sodium alginate is the sodium salt of alginic acid, a naturally occurring polysaccharide found in brown algae. It is commonly used as a stabilizer and thickener in the food industry. Sodium alginate can crosslink in the presence of divalent cations such as Ca2+ to form stable, biodegradable gels, which find applications as a material for cell encapsulation and immobilization.

Corbiocel Nanocellulose

Cellulose nanofiber is a material isolated from plant cell walls by the deconstruction of cellulose. It exhibits high viscosity at low material concentrations due to its large surface area and high carboxyl group content.

Low melting point Agarose

Agar belongs to the galactan polysaccharide family, which constitutes the intracellular matrix in red algae/seaweeds belonging to the Rhodophyta class. Agar is naturally slightly sulfated and is a complex mixture of polysaccharides. Agarose is a neutral polymeric component of agar. Heating agarose results in a solution that, upon cooling, transforms into a gel. Gel formation occurs due to the double helical formation of the molecular chains, which forms a water-locking network.

GelMA (Gelatinmethacryloyl)

Gelatin methacrylate (GelMA)-based bioinks have recently gained increasing attention in the field of biomedical applications due to their high cellular biocompatibility and their ability to form polymerized hydrogels in the presence of a photoinitiator.

Numerous research projects and collaborative groups have demonstrated that GelMA bioinks have significant potential for generating living tissues with diverse 3D architectures using additive manufacturing strategies. Furthermore, they have a wide range of applications in tissue engineering, including the regeneration or repair of bone, cartilage, the nervous system, skin, skeletal muscle, and cardiac tissue.

Standard Agarose

Agar belongs to the galactan polysaccharide family, which constitutes the intracellular matrix in red algae/seaweeds belonging to the Rhodophyta class. Agar is naturally slightly sulfated and is a complex mixture of polysaccharides. Agarose is a neutral polymeric component of agar. Heating agarose results in a solution that, upon cooling, transforms into a gel. Gel formation occurs due to the double helical formation of the molecular chains, which forms a water-locking network.

Gelatin

Gelatin is a heterogeneous mixture of water-soluble proteins with high average molecular weights, present in collagen. The proteins are extracted by boiling skin, tendons, ligaments, bones, etc. in water. Type A gelatin is derived from acid-cured tissue, and type B gelatin is derived from lime-cured tissue.

©MicroPhysiology 2024

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