ClinoStar 2
CelVivo - 3D Cell Culture System
The ClinoStar 2 by CelVivo is an advanced 3D cell culture incubator designed to cultivate spheroids and organoids under low-shear, in vivo-like conditions. Featuring six independently controlled bioreactors, remote monitoring via CelVivo Cloud, and optional hypoxia control, it enables precise, long-term tissue modeling for biomedical research.
Introducing: ClinoStar 2
Have you ever considered how to unleash the hidden potential of cell communication
and tissue formation? The ClinoStar system is at the forefront of this scientific pursuit,
offering a solution that raises a provocative question: Why is it crucial for researchers
to embrace the clinostat principle and eliminate shear stress in their work?
Shear stress is a mechanical force exerted by fluid flow on cells. When cells encounter excessive shear stress, they undergo mechanotransduction, triggering changes in gene expression and protein synthesis.
By using ClinoStar 2, you’ll avoid this.
In vivo just moved closer: Experience ClinoStar 2
ClinoStar 2 features
Control the temperature, CO2, O2 (optional), and the individual rotational speed of the six clinostat axles.
Monitor your constructions in each reactor through six live feed cameras.
4 to 6 times as much biomass per volume of media compared to traditional cell culture systems.
The inbuilt humidification system minimises the risk of infections and secures constant media volume.
More Features
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Each reactor has an associated motor that can spin the reactor slowly. The speed of the motor can be precisely controlled individually and remote using any internet-enabled device.
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A fan is installed in the chamber for ventilation purposes to ensure a uniform environment within the chamber.
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For decontamination a UV-C beacon is placed in the chamber.
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The door has a push to open mechanism allowing the user to open the door with the elbow, so the hands of the user can be used for holding bioreactors.
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The door functions as a whiteboard making it possible to write notes directly on the system.
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The unit has a small footprint and can be stacked up to 3 units high.
CelVivo Cloud
Connecting Your Research to the Cloud
It’s never been easier to control, monitor, and manage your cell culture. With CelVivo Cloud, your ClinoStar can be remotely controlled from any internet-enabled device – anywhere in the world!
The online software platform makes it easy to adjust the climate settings in your ClinoStar through control of temperature, CO2, and O2.
Other Features
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Access your ClinoStar through multiple devices from anywhere.
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Monitor your cultures and adjust individual rotational speeds as they progress.
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Keep a register of changes and updates through the event log.
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Automatic UV-C decontamination cycles can be remotely initiated.
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Give team members individual control over certain ClinoStars.
Hypoxia Unit
The CelVivo Hypoxia Module for ClinoStar enables precise oxygen control from atmospheric levels down to 2%, replicating physiological conditions found in tissues like lungs, brain, and tumors. It ensures rapid oxygen level stabilization and maintains hypoxic environments during brief exposures, enhancing the accuracy and reproducibility of 3D cell culture experiments.
APPLICATIONS
LIVER
3D structures can be used to study many aspects of liver function, including development, disease modeling (including NASH or fibrosis), cancer, drug screening for efficacy, and toxicology.